Bombesin receptors in GtoPdb v.2023.1

Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on receptors, [117, 4]). BB1 and BB2 are activated endogenous ligands neuromedin B (NMB), gastrin-releasing peptide (GRP), GRP-(18-27). is a tetra-decapeptide, originally derived from amphibians structurally closely related to GRP. The three Bn receptor subtypes couple primarily Gq/11 G12/13 family of G proteins [117]. Each these widely distributed in CNS peripheral tissues [80, 117, 261, 290, 248, 375, 114, 164, 165]. Activation causes wide range physiological/pathophysiogical actions, including stimulation normal neoplastic tissue growth, smooth-muscle contraction, respiration, gastrointestinal motility, feeding behavior, secretion many central nervous system effects regulation circadian rhythm, body temperature control, sighing, behavioral disorders mediation pruritus [153, 211, 255, 205, 318, 70, 35, 345, 212, 36]. an orphan receptor, although some propose it constitutively active [330]. knockout studies show has important roles glucose insulin regulation, metabolic homeostasis, feeding, temperature, obesity, diabetes mellitus growth normal/neoplastic [152, 80, 168, 224, 359, 209]. one most frequently overexpressed cancers receiving increased attention for their tumor as well tumour imaging receptor-targeted cytotoxicity [211, 288, 9, 167, 171, 172, 135, 202]. also because they primary neurotransmitters [36, 127, 318].